Monday, 28 November 2011

Laboratory Synthesis Of Amitriptyline

preparation of  Amitriptyline
Amitriptyline IUPAC Chemical Name: 3- (10 ,11- di hydro- 5 H- di benzo [a ,d ]cyclo hepten- 5- ylidene)- N ,N- di methyl- 1- propanamine
Amitriptyline Use: antidepressant
Amitriptyline MW: 277.41
Amitriptyline MF: C20H23N
Amitriptyline LD50: 16 mg/kg (M, i.v.); 140 mg/kg (M, p.o.);320 mg/kg (R, p.o.)
  • GB 858 187 (Hoffmann-La Roche; appl. 24.3.1959; CH-prior. 3.4.1958).
DE 1 109 166 (Hoffmann-La Roche; appl. 16.3.1959; CH-prior. 3.4.1958).
BE 584 061 (Merck & Co.; appl. 27.10.1959; USA-prior. 31.10.1958).
BE 609 095 (Kefalas A/S; appl. 12.10.1961; DK-prior. 12.10.1960).
  •  Hoffsommer, R.D. et al.: J. Org. Chem. (JOCEAH) 27, 4134 (1962).
alternative synthesis Amitriptyline
DAS 1 468 138 (Kefalas; appl. 12.3.1963; GB-prior. 23.3.1962, 9.11.1962).
US 3 205 264 (Merck & Co.; 7.9.1965; appl. 15.6.1962).

tags-synthesis of drugs,method of preparation of Amitriptyline ,molecular weight Amitriptyline  , molecular formula of Amitriptyline,structure of Amitriptyline  


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