Laboratory Synthesis Of Amoxicillin

Amoxicillin IUPAC Chemical Name: [2 S- [2 a ,5 a ,6 b (S *)]]-6- [[amino (4- hydroxy phenyl )acetyl ]amino]- 3 ,3- di methyl- 7- oxo- 4-thia- 1- aza bi cyclo [3 .2 .0 ]heptane- 2- carboxylic acid
Amoxicillin Use: antibiotic
Amoxicillin MW: 365.41
Amoxicillin MF: C16H19N3O5S
Amoxicillin LD50: >25 g/kg (M, p.o.);>15 g/kg (R, p.o.)

Amoxicillin Reference(s):
"racemic amoxicillin":
GB 978 178 (Beecham; appl. 2.11.1962; valid from 25.10.1963).
US 3 192 198 (Beecham; 29.6.1965; GB-prior. 2.11.1962).
amoxicillin:
Long, A.A.W. et al.: J. Chem. Soc. C (JSOOAX) 1971, 1920.
US 3 674 776 (Beecham; 4.7.1972; appl. 18.8.1969; GB-prior. 23.8.1968).
DOS 1 942 693 (Beecham; appl. 21.8.1969; GB-prior. 23.8.1968).
GB 1 241 844 (Beecham; appl. 23.8.1968; valid from 20.8.1969).
a US 4 128 547 (Gist-Brocades; 5.12.1978; NL-prior. 6.9.1977).
GB 1 339 605 (Beecham; appl. 1.4.1971; valid from 28.3.1972).
b DAS 2 611 286 (Bristol-Myers; appl. 17.3.1976; USA Prior. 17.3.1975).
alternative syntheses Amoxicillin:
US 4 053 360 (Bristol-Myers; 11.10.1977; GB-prior. 5.6.1974, 19.3.1975).
DOS 2 454 841 (Archifar; appl. 19.11.1974; I-prior. 17.5.1974).
DOS 2 755 903 (Dobfar; appl. 15.12.1977; I-prior. 16.12.1976).
GB 1 535 291 (Bristol-Myers; appl. 5.3.1976; USA-prior. 17.3.1975).
US 4 098 796 (Novo; 4.7.1978; appl. 7.6.1976).
BE 867 414 (Antibioticos S.A.; appl. 24.5.1978; E-prior. 4.6.1977).
microbiologic acylation of 6-APA with methyl D-a-(4-hydroxyphenyl)-glycinate hydrochloride
by means of Aphanocladium aranearum (ATCC 20453):
US 4 073 687 (Shionogi; 14.2.1978; J-prior. 14.5.1975).
sodium salt:
GB 1 543 317 (Beecham; valid from 4.8.1976; prior. 27.9.1975).
DOS 2 729 112 (Beecham; appl. 28.6.1977; GB-prior. 7.7.1976).
trihydrate:
DAS 2 611 286 (Bristol-Myers; appl. 17.3.1976; USA-prior. 17.3.1975).
DOS 2 732 528 (Bristol-Myers; appl. 19.7.1977; GB-prior. 20.7.1976).
water soluble salts with arginine or lysine:
GB 1 504 767 (Beecham; valid from 23.8.1976; prior. 2.7.1975, 30.9.1975; 3.11.1975).
GB 1 539 510 (Beecham; valid from 23.8.1976; prior. 23.8.1975, 30.9.1975, 3.11.1975).
"amorphous" amoxicillin:
DAS 2 112 634 (Beecham; appl. 16.3.1971; GB-prior. 16.3.1970).
formulation for injection solutions:
GB 1 532 993 (Beecham; appl. 7.3.1975; valid from 9.2.1976).

tags-synthesis of drugs,method of preparation of Amoxicillin,molecular weight Amoxicillin  , molecular formula of Amoxicillin,structure of Amoxicillin