Saturday, 12 May 2012

Laboratory Synthesis Of Carvedilol

Carvedilol Synthesis 

Use: non-selective b1-adrenoceptor blocker with vasodilating activity
MW: 406.48
MF: C24H26N2O4
LD50:     364 mg/kg (M, i.p.); 27 mg/kg (M, i.v.);
    769 mg/kg (R, i.p.); 25 mg/kg (R, i.v.);
    >1 g/kg (dog, p.o.)
Synthesis References
  1. Drugs Fut1983,8,(10):841
  2. DE 2815926; EP 0004920; ES 479396; JP 54157558; US 4503067
  3. EP 0918055

1 comment:

  1. Carvedilol drug is one of the effective beta blockers for preventing ventricular tachyarrhythmias in heart failure, but the mechanisms underlying its favorable antiarrhythmic benefits remain unclear. Spontaneous waves, also called store overload-induced release , evoke ventricular tachyarrhythmias in individuals with heart failure.