Tuesday 15 May 2012

Laboratory Synthesis Of Fenclofenac

Fenclofenac Synthesis
Use: anti-inflammatory, analgesic
RN: 34645-84-6 EINECS: 252-126-2
MW: 297.14 MF: C14H10Cl2O3
LD50: 2280 mg/kg (R, p.o.)
IUPAC: 2- (2 ,4- di chloro phenoxy )benzene acetic acid





The reaction of 2,4-dichlorophenol with 2-chloroacetophenone  by means of a copper catalyst and sodium hydroxide gives 2-(2,4-dichlorophenoxy)acetophenone , which is treated with sulfur in refluxing morpholine yielding 2-(2,4-dichlorophenoxy)phenylthioacetomorpholide . Finally this compound is hydrolyzed with KOH in refluxing methanol

SYNTHESIS REFERENCE


Click here to see the US patent—CLICK HERE


  1. DE 2 117 826 (Reckitt & Colman; appl. 13.4.1971; GB-prior. 14.4.1970).
  2. GB 1 308 327 (Reckitt & Colman; valid from 19.4.1971; prior. 14.4.1970).
  3. US 3 766 263 (Reckitt & Colman; 16.10.1973; GB-prior. 14.4.1970).
  4. Drugs Fut1977, 2, (10):665
  5. FR 2092044



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