Laboratory Synthesis Of Amsacrine

Amsacrine IUPAC Chemical Name: N- [4- (9- acridinyl amino)- 3- methoxy phenyl ]methane sulfon amide
Amsacrine Use: antineoplastic
Amsacrine MW: 393.47
Amsacrine MF: C21H19N3O3S
Amsacrine LD50: 33.7 mg/kg (M, i.v.); 53.42 mg/kg (M, p.o.);6.25 mg/kg (dog, i.v.); 50 mg/kg (dog, p.o.)
Amsacrine Reference(s):
Cain, B.F. et al.: J. Med. Chem. (JMCMAR) 18, 1110 (1975); 20, 987 (1977).
Denny, W.A. et al.: J. Med. Chem. (JMCMAR) 21, 5 (1978).
Rewcastle, G.W. et al.: J. Med. Chem. (JMCMAR) 25, 1231 (1982).
preparation of III from benzenediazonium chloride:
Wilson, W.R. et al.: J. Med. Chem. (JMCMAR) 32, 23 (1989).

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