Laboratory Synthesis Of Amantadine

Amantadine IUPAC Chemical name: tri cyclo [3 .3 .1 .1 3 ,7 ]decan- 1- amine
Amantadine Use: antiparkinsonian, antiviral
Amantadine MW: 151.25 MF: C10H17N
Amantadine LD50: 700 mg/kg (M, p.o.);900 mg/kg (R, p.o.)
Reference(s):

1. Stetter, H. et al.: Chem. Ber. (CHBEAM) 93, 226 (1960).US 3 310 469 (Du Pont; 21.3.1967; prior. 28.8.1961, 15.4.1963, 22.10.1963).
2. synthesis from adamantane, HCN and H2SO4:US 3 152 180 (Studiengesellschaft Kohle; 6.10.1964, D-prior. 25.8.1960).
3. combination with molindone (antidepressant):US 4 148 896 (Du Pont; 10.4.1979; appl. 22.2.1978).

tags-synthesis of drugs,method of preparation of Amantadine ,molecular weight Amantadine , molecular formula of  Amantadine,structre of Amantadine