Laboratory Synthesis Of Allopurinol

Allopurinol IUPAC Chemical Name: 1 ,5- di hydro- 4 H- pyrazolo [3 ,4- d ]pyrimidin- 4- one
Allopurinol Use: uricosuric agent
Allopurinol MW: 136.11 MF: C5H4N4O
Allopurinol LD50: >1 g/kg (M, p.o.)
Reference(s):

1. US 2 868 803 (Ciba; 13.1.1959; CH-prior. 10.2.1956).
2. DAS 1 720 024 (Wellcome Found; appl. 12.7.1967; GB-prior. 14.7.1966).

Similar process:

1. DAS 1 904 894 (Wellcome Found; appl. 31.1.1969; GB-prior. 2.2.1968).
2. US 4 146 713 (Burroughs Wellcome; 27.3.1979; GB-prior. 2.2.1968).

Alternative syntheses:

1. US 3 474 098 (Burroughs Wellcome; 21.10.1969; prior. 29.3.1956).
2. DAS 2 224 382 (Henning Berlin; appl. 18.5.1972).
3. DE 1 118 221 (Wellcome Found; appl. 4.8.1956; GB-prior. 10.8.1955).
4. DAS 1 814 082 (Wellcome Found; appl. 11.12.1968).
5. DAS 1 950 075 (Henning Berlin; appl. 3.10.1969).

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