Laboratory Synthesis Of Ambroxol

Ambroxol IUPAC Chemical Name: trans- 4- [[(2- amino- 3 ,5- di bromo phenyl )methyl ]amino ]cyclo hexanol
Ambroxol Use: expectorant
Ambroxol MW: 378.11
Ambroxol MF: C13H18Br2N2O
Ambroxol LD50: 138 mg/kg (M, i.v.); 2720 mg/kg (M, p.o.);13.4 g/kg (R, p.o.)
Reference(s):

1. DE 1 593 579 (Thomae; appl. 10.5.1966).
2. DOS 2 218 647 (Thomae; appl. 18.4.1972).
3. DOS 2 223 193 (Thomae; appl. 12.5.1972).
4. Keck, J.: Justus Liebigs Ann. Chem. (JLACBF) 707, 107 (1967).

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