Laboratory Synthesis Of Amiloride

Amiloride IUPAC Chemical Name: 3 ,5- di amino- N- (amino imino methyl)- 6- chloro pyrazine carbox amide
Amiloride Use: diuretic, antihypertonic
Amiloride MW: 229.63
Amiloride MF: C6H8ClN7O
Amiloride Reference(s):

1. US 3 313 813 (Merck & Co.; 11.4.1967; prior. 30.10.1962, 7.10.1963).
2. GB 1 066 855 (Merck & Co.; appl. 24.10.1963; USA-prior. 30.10.1962, 7.10.1963).
3. Bicking, J.B. et al.: J. Med. Chem. (JMCMAR) 8, 638 (1965).
4. Cragoe, E.J. et al.: J. Med. Chem. (JMCMAR) 10, 66 (1967).

improved method for 5,6-diaminouracil:

1. DOS 2 831 037 (Lonza; appl. 14.7.1978; CH-prior. 20.7.1977).

combination with etacrynic acid:

1. US 3 781 430 (Merck & Co.; 25.12.1973; prior. 30.10.1962, 7.10.1963, 7.2.1966, 18.2.1969,

21.12.1971).

tags-synthesis of drugs,method of preparation of Amiloride ,molecular weight Amiloride , molecular formula of  Amiloride,structure of Amiloride