Laboratory Synthesis Of Ampicillin

Amsacrine IUPAC Chemical Name: [2 S- [2 a ,5 a ,6 b (S *)]]-6- [(amino phenyl acetyl )amino]- 3 ,3- di methyl- 7- oxo- 4- thia- 1- aza bicyclo [3 .2 .0 ]heptane- 2- carboxylic acid
Amsacrine Use: antibiotic
Amsacrine MW: 349.41
Amsacrine MF: C16H19N3O4S
Amsacrine LD50: 4600 mg/kg (M, i.v.); >5 g/kg (M, p.o.);6200 mg/kg (R, i.v.)
Amsacrine Reference(s):
a GB 893 049 (Beecham; appl. 6.10.1958, 12.5.1959).
GB 902 703 (Beecham; valid from 19.5.1961; prior. 25.8.1960).
US 2 985 648 (Beecham; 23.5.1961; GB-prior. 6.10.1958).
DAS 1 139 844 (Beecham; appl. 6.10.1959; GB-prior. 6.10.1958, 12.5.1960).
DE 1 156 078 (Beecham; appl. 29.5.1961; GB-prior. 25.8.1960).
b US 3 140 282 (Bristol-Myers; 7.7.1964; appl. 5.3.1962).
c GB 991 586 (Beecham; appl. 28.2.1963, 3.12.1963; valid from 13.2.1964).
alternative syntheses:
DE 1 168 910 (Beecham; appl. 3.7.1962; GB-prior. 21.7.1961).
US 3 144 445 (American Home; 11.8.1964; appl. 26.12.1962).
DAS 1 445 506 (Bristol-Myers; appl. 24.10.1963; USA-prior. 29.10.1962).
DAS 1 545 534 (Astra; appl. 4.3.1965; S-prior. 6.3.1964).
DAS 2 029 195 (Yamanouchi; appl. 13.6.1970; J-prior. 16.6.1969).
DAS 1 800 698 (American Home Products; appl. 2.10.1968; USA-prior. 2.10.1967).
DOS 2 755 903 (Dobfar; appl. 15.12.1977; I-prior. 16.12.1976).
enzymatic and microbiological methods:
US 3 079 307 (Bayer; 26.2.1963; D-prior. 7.10.1961).
DE 1 966 521 (Kyowa Hakko; appl. 9.9.1969; J-prior. 18.9.1968, 8.10.1968).
DAS 1 967 074 (Kyowa Hakko; appl. 9.9.1969; J-prior. 18.9.1968, 8.10.1968).
DAS 2 050 983 (Kyowa Hakko; appl. 16.10.1970; J-prior. 16.10.1969).
US 4 073 687 (Shionogi; 14.2.1978; J-prior. 14.5.1975).
ampicillin salts:
DE 1 197 460 (Bayer; appl. 4.9.1962).
DOS 1 670 111 (Bristol-Myers; appl. 16.7.1966).
DE 1 670 191 (Beecham; appl. 24.2.1967; GB-prior. 3.3.1966).
DAS 1 795 129 (Beecham; appl. 14.8.1968; USA-prior. 18.8.1967).

tags-synthesis of drugs,method of preparation of Ampicillin,molecular weight Ampicillin  , molecular formula of Ampicillin,structure of Ampicillin